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Yeast Fitness

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YFR027W / ECO1

Section 1: Phenotypes.
Gene-drug relationships for YFR027W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YFR027W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ECO1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorocytosine 15.6 uM 8.3231 4.3759e-11
bithionol 75 uM 7.03754 3.5863e-09
methotrexate 500 uM 6.83449 4.9634e-08
methotrexate 500 uM 6.48608 1.3388e-07
5-fluorocytosine 15.6 uM 6.44476 2.8478e-08
methotrexate 500 uM 5.86578 8.0068e-07
mycophenolic acid 500 uM 4.96111 4.7967e-06
phenoxybenzamine hydrochloride 500 uM 4.93077 5.3134e-06
fluconazole 16.3 uM 4.88469 6.2048e-06
5-fluorocytosine 15.6 uM 4.83667 7.2903e-06

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YFR027W

Top 10 functional gene interactors with YFR027W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with ECO1 by heterozygous co-sensitivity:

Query Interactor Correlation
ECO1 SRP40 0.35126
ECO1 POL1 0.34217
ECO1 SPF1 0.33782
ECO1 MDM12 0.32959
ECO1 POL2 0.32848
ECO1 PIH1 0.32615
ECO1 RAD23 0.3244
ECO1 RIB7 0.32251
ECO1 RMP1 0.31487
ECO1 BRL1 0.31346

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YFR027W

Other databases:

Visit YFR027W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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