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Yeast Fitness
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YFL063W / YFL063W



Section 1: Phenotypes.
Gene-drug relationships for YFL063W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YFL063W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YFL063W Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
berberine chloride 125 uM 20.0231 < 1e-12
methotrexate 250 uM 7.00278 3.0855e-08
methotrexate 500 uM 4.75598 2.0168e-05
methotrexate 250 uM 4.74095 2.1064e-05
methotrexate 125 uM 4.1699 0.00010839
xanthohumol 6.2 uM 4.14803 0.00011532
fk506 0.05 ug/ml 4.07697 0.00014099
itraconazole 17.7 uM 3.98956 0.00011512
itraconazole 17.7 uM 3.98116 0.0001182
nacl 500 mM 3.88267 0.00024321

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YFL063W Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mechlorethamine 62.5 uM 6.59201 0.011124
synthetic complete for BY4743 0 4.59086 0.0050501
synthetic complete for BY4743 0 4.55384 0.022496
synthetic complete for BY4743 0 3.5439 0.0082471
synthetic complete for BY4743 0 3.3285 0.0063085
synthetic complete for BY4743 0 2.84171 0.023393
mms 0.002 % 2.6369 0.059371
latrunculin 3 uM 2.56222 0.0097961
nacl 600 mM 2.55328 0.007664
synthetic complete for BY4743 0 2.53446 0.019489

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YFL063W

Top 10 functional gene interactors with YFL063W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YFL063W by heterozygous co-sensitivity:

Query Interactor Correlation
YFL063W DUS3 0.70142
YFL063W YKL187C 0.68989
YFL063W PLB2 0.688
YFL063W YAR030C 0.65444
YFL063W MF(ALPHA)1 0.64796
YFL063W PLB1 0.64141
YFL063W CPR2 0.64029
YFL063W SMK1 0.63609
YFL063W YLR001C 0.63187
YFL063W MRPL39 0.62972

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YFL063W by homozygous co-sensitivity:

Query Interactor Correlation
YFL063W MAL12 0.67986
YFL063W GAS2 0.66889
YFL063W YPR117W 0.66727
YFL063W YGR079W 0.66276
YFL063W YJL068C 0.64089
YFL063W YAR037W_d 0.63854
YFL063W REC114 0.63026
YFL063W CUE4 0.62969
YFL063W YAL061W 0.62949
YFL063W YAL045C 0.62891

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None




External information about YFL063W

Other databases:

Visit YFL063W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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