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YER168C / CCA1



Section 1: Phenotypes.
Gene-drug relationships for YER168C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER168C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CCA1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
trichostatin A 3.91 uM 6.34852 1.9863e-07
methotrexate 250 uM 4.95237 4.9402e-06
acriflavinium hydrochloride 250 uM 4.1904 6.0858e-05
fusarubin 250 uM 3.66813 0.00044041
progesterone 250 uM 3.57814 0.0004078
amphotericin b 0.31 uM 3.4958 0.00052139
dyclonine 500 uM 3.48607 0.00053666
thiabendazole 500 uM 3.46454 0.00057196
quinacrine hydrochloride 1000 uM 3.3868 0.00071879
terreic acid 1000 uM 3.3605 0.0010129

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YER168C

Top 10 functional gene interactors with YER168C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with CCA1 by heterozygous co-sensitivity:

Query Interactor Correlation
CCA1 BUR6 0.76668
CCA1 RAD3 0.7433
CCA1 YGR251W 0.71175
CCA1 BRR2 0.71063
CCA1 OCH1 0.70682
CCA1 SLD3 0.70196
CCA1 SMP3 0.70024
CCA1 SEC9 0.69697
CCA1 UTP20 0.69531
CCA1 SEC1 0.69275

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YER168C

Other databases:

Visit YER168C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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