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Yeast Fitness
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YER166W / DNF1



Section 1: Phenotypes.
Gene-drug relationships for YER166W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER166W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for DNF1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 13.9136 < 1e-12
dyclonine 500 uM 13.5791 6.0299e-09
dyclonine 500 uM 13.2082 8.246e-09
wiskostatin 29 uM 13.1087 < 1e-12
aphidicolin glycinate 125 uM 10.7015 2.1033e-12
clozapine 500 uM 9.29864 3.2105e-12
trichostatin A 3.91 uM 8.60733 3.8851e-10
telomerase inhibitor ix (Biomol) 500 uM 7.53712 6.9532e-09
papuamide b 0.37 ug/ml 5.82641 8.9757e-07
atorvastatin 125 uM 5.73716 3.356e-07

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for DNF1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 27.2325 < 1e-12
rapamycin 6 nM 23.9402 < 1e-12
nocodazole 10 ug/ml 14.4593 1.1894e-11
rapamycin 4.88 nM 13.2386 < 1e-12
rapamycin 9 nM 12.701 0.003071
papuamide b 1 ug/ml 10.8391 < 1e-12
synthetic complete for BY4743 0 9.43502 0.0012616
calyculin a 2.5 uM 8.4308 3.8078e-10
latrunculin 0.78 uM 7.79286 0.0080354
latrunculin 3 uM 7.03988 7.1975e-07

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YER166W

Top 10 functional gene interactors with YER166W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with DNF1 by heterozygous co-sensitivity:

Query Interactor Correlation
DNF1 SHO1 0.64983
DNF1 NEJ1 0.55437
DNF1 YJL182C 0.49229
DNF1 YER188W 0.44983
DNF1 YKL023W 0.43938
DNF1 YCR050C 0.4214
DNF1 YLF2 0.41744
DNF1 YIH1 0.41079
DNF1 YCL001W-A 0.40826
DNF1 YCR087W 0.40805

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with DNF1 by homozygous co-sensitivity:

Query Interactor Correlation
DNF1 MLP1 0.69662
DNF1 YPR091C 0.69618
DNF1 TOM71 0.66793
DNF1 SCS2 0.66432
DNF1 YLF2 0.65398
DNF1 DNF2 0.63571
DNF1 PEA2 0.6089
DNF1 AGA1 0.60424
DNF1 YDR415C 0.59341
DNF1 FLC2 0.58304

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YER166W

Other databases:

Visit YER166W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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