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Yeast Fitness
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YER155C / BEM2



Section 1: Phenotypes.
Gene-drug relationships for YER155C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER155C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for BEM2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dyclonine 500 uM 6.75622 1.0129e-05
dna protein kinase inhibitor 0 6.71621 6.9433e-08
dyclonine 500 uM 6.2425 2.1513e-05
myriocin 0.15 ug/ml 5.98677 5.6389e-07
dihydromotuporamine C 15 uM 5.4357 2.7956e-06
methotrexate 125 uM 4.25353 4.9687e-05
alverine citrate 500 uM 4.167 6.5588e-05
atorvastatin 125 uM 3.68259 0.00029749
aphidicolin glycinate 125 uM 3.65484 0.00045676
trichostatin A 3.91 uM 3.46214 0.00077129

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for BEM2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 0.78 uM 5.69625 1.0559e-05
potassium disulfite 2500 uM 5.67708 1.099e-05
nocodazole 10 ug/ml 5.13357 3.4798e-05
no drug irradiated 0 4.948 5.1957e-05
angelicin 62.5 uM 4.67506 9.4239e-05
rapamycin 9 nM 4.61945 0.021903
latrunculin 0.78 uM 4.09572 0.027381
latrunculin 0.78 uM 4.06476 0.00036353
bleomycin 1.13 ug/ml 3.55191 0.0011391
mechlorethamine 62.5 uM 3.20024 0.042665

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YER155C

Top 10 functional gene interactors with YER155C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with BEM2 by heterozygous co-sensitivity:

Query Interactor Correlation
BEM2 LDB16 0.57007
BEM2 PSY2 0.56112
BEM2 YGR122W 0.53517
BEM2 YBL010C 0.51106
BEM2 TYW3 0.47807
BEM2 YGL118C 0.47622
BEM2 MTM1 0.46749
BEM2 MMS2 0.45917
BEM2 MRPL25 0.45868
BEM2 CDC37 0.4565

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YER155C

Other databases:

Visit YER155C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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