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Yeast Fitness
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YER151C / UBP3



Section 1: Phenotypes.
Gene-drug relationships for YER151C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER151C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for UBP3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dihydromotuporamine C 15 uM 7.56949 6.3593e-09
dna protein kinase inhibitor 0 7.21665 1.6932e-08
wiskostatin 29 uM 6.25875 2.5714e-07
neomycin sulfate 100 uM 6.14792 3.5392e-07
latrunculin 3.91 uM 5.69886 1.3e-06
methotrexate 500 uM 4.65906 2.6691e-05
nacl 700 mM 4.29664 7.5583e-05
licl 150 mM 4.21544 9.5246e-05
trichostatin A 3.91 uM 4.16439 0.0001101
atorvastatin 125 uM 3.48507 0.00053824

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for UBP3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 0.78 uM 34.0354 0.00043107
rapamycin 9 nM 17.7888 0.0015726
licl 100 mM 15.4323 4.0025e-12
ph4 7.5 14.5536 1.0674e-11
nocodazole 10 ug/ml 14.1328 1.7384e-11
latrunculin 0.78 uM 14.0644 1.8839e-11
latrunculin 0.78 uM 13.5773 0.0004321
myriocin 0.2 ug/ml 10.3632 2.5716e-09
potassium disulfite 2500 uM 10.0383 4.2103e-09
bleomycin 1.13 ug/ml 9.8968 5.2372e-09

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YER151C

Top 10 functional gene interactors with YER151C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with UBP3 by heterozygous co-sensitivity:

Query Interactor Correlation
UBP3 SAC3 0.5514
UBP3 ERV1 0.5507
UBP3 PET122 0.54308
UBP3 ALF1 0.53582
UBP3 MCM6 0.53499
UBP3 OXA1 0.52613
UBP3 CSE1 0.52606
UBP3 SEC9 0.51972
UBP3 SPC19 0.51937
UBP3 NUP116 0.51872

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with UBP3 by homozygous co-sensitivity:

Query Interactor Correlation
UBP3 BRE5 0.54717
UBP3 PKR1 0.37551
UBP3 ADE3 0.35816
UBP3 YOR366W 0.35213
UBP3 VTS1 0.33955
UBP3 YOL087C 0.3253
UBP3 URE2 0.32303
UBP3 RPS19A 0.31778
UBP3 VPH1 0.3158
UBP3 RAV1 0.30548

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YER151C

Other databases:

Visit YER151C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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