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Yeast Fitness
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YER145C / FTR1



Section 1: Phenotypes.
Gene-drug relationships for YER145C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER145C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for FTR1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
trichostatin A 3.91 uM 6.17395 3.2831e-07
terreic acid 1000 uM 4.73675 2.1322e-05
fenpropimorph 4.7 uM 4.28551 4.4818e-05
itraconazole 17.7 uM 3.70482 0.00027803
thiabendazole 500 uM 3.52691 0.00047532
dyclonine 500 uM 3.51442 0.00049332
caspofungin 10 nM 3.31078 0.00089658
chlorambucil 1000 uM 3.27349 0.00099833
bisphenol s 100 uM 3.19925 0.0012343
itraconazole 17.7 uM 3.02074 0.0020349

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for FTR1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 91.3418 5.9917e-05
synthetic complete for BY4743 0 83.592 7.154e-05
minimal media 0 45.0531 < 1e-12
synthetic complete for BY4743 0 33.6808 0.00044018
synthetic complete for BY4743 0 33.2072 3.0014e-05
synthetic complete for BY4743 0 32.77 2.4864e-07
latrunculin 0.78 uM 29.6301 0.00056854
synthetic complete for BY4743 0 28.8999 4.6477e-07
yp glycerol 0 28.339 3.4802e-11
synthetic complete for BY4743 0 26.8548 6.6947e-07

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YER145C

Top 10 functional gene interactors with YER145C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with FTR1 by heterozygous co-sensitivity:

Query Interactor Correlation
FTR1 YER134C 0.56602
FTR1 YER184C 0.55765
FTR1 FET3 0.53658
FTR1 ADP1 0.53592
FTR1 FZF1 0.52651
FTR1 SAK1 0.5193
FTR1 GLG1 0.51875
FTR1 YKL107W 0.51387
FTR1 ISC10 0.50884
FTR1 AVT6 0.50294

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with FTR1 by homozygous co-sensitivity:

Query Interactor Correlation
FTR1 FET3 0.86642
FTR1 YDR269C 0.72848
FTR1 CCC2 0.69266
FTR1 YMR057C 0.66364
FTR1 ATX1 0.60684
FTR1 YDR271C 0.60676
FTR1 YMR258C 0.60165
FTR1 BRO1 0.57771
FTR1 GRX3 0.55858
FTR1 DID2 0.55807

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YER145C

Other databases:

Visit YER145C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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