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YER133W / GLC7

Section 1: Phenotypes.
Gene-drug relationships for YER133W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER133W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GLC7 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 250 uM 31.9178 0.00049008
cantharidin 250 uM 26.2495 < 1e-12
cantharidin disodium 100 uM 25.4085 < 1e-12
sodium sulfate 625 uM 24.5613 < 1e-12
methotrexate 125 uM 23.8683 < 1e-12
calyculin a 2.5 uM 23.6633 < 1e-12
methotrexate 125 uM 23.3649 < 1e-12
cantharidin 100 uM 21.5573 < 1e-12
methotrexate 250 uM 20.149 < 1e-12
cantharidin 250 uM 19.3171 0.0013346

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YER133W

Top 10 functional gene interactors with YER133W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with GLC7 by heterozygous co-sensitivity:

Query Interactor Correlation
GLC7 SPT16 0.43454
GLC7 TUP1 0.40238
GLC7 THP1 0.37799
GLC7 SWD2 0.37043
GLC7 CYC8 0.36312
GLC7 SSU72 0.35041
GLC7 YDR532C 0.34328
GLC7 YKL036C 0.3291
GLC7 YBL065W 0.32655
GLC7 MED4 0.32405

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YER133W

Other databases:

Visit YER133W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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