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Yeast Fitness
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YER123W / YCK3



Section 1: Phenotypes.
Gene-drug relationships for YER123W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER123W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YCK3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
trichostatin A 3.91 uM 11.2106 < 1e-12
hygromycin 0.4 uM 3.96177 0.00012561
progesterone 250 uM 3.87785 0.00016323
fk506 0.1 ug/ml 3.6804 0.00042581
resveratrol 2000 uM 3.43988 0.00081893
tryptanthrin 250 uM 3.28612 0.0012342
thiabendazole 500 uM 3.26962 0.0010095
fk506 0.1 ug/ml 3.26279 0.0013126
latrunculin 6.25 uM 3.25956 0.0024605
aureobasidin a 0.02 ug/ml 3.20525 0.0015271

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YCK3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
tryptophan dropout 0 17.0824 4.9832e-09
synthetic complete for BY4743 0 17.0541 5.0638e-09
synthetic complete for BY4743 0 16.4739 7.0807e-09
synthetic complete for BY4743 0 15.3342 1.4142e-08
papuamide b 1 ug/ml 12.9696 < 1e-12
papuamide b 0.7 ug/ml 12.8852 < 1e-12
wiskostatin 29 uM 12.4401 < 1e-12
rapamycin 6 nM 12.1799 < 1e-12
rapamycin 4.88 nM 12.1551 < 1e-12
zncl2 1875 uM 11.8697 < 1e-12

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YER123W

Top 10 functional gene interactors with YER123W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YCK3 by heterozygous co-sensitivity:

Query Interactor Correlation
YCK3 KAP123 0.60921
YCK3 CCA1 0.58172
YCK3 BUB2 0.57535
YCK3 YER156C 0.57096
YCK3 DSE1 0.5647
YCK3 SEC1 0.56056
YCK3 YER119C-A 0.55769
YCK3 COR1 0.55443
YCK3 GDI1 0.55198
YCK3 CUE3 0.55138

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YCK3 by homozygous co-sensitivity:

Query Interactor Correlation
YCK3 APS3 0.59068
YCK3 APM3 0.5893
YCK3 APL6 0.56315
YCK3 SCS2 0.51324
YCK3 SWP82 0.46693
YCK3 YPT7 0.42628
YCK3 HLJ1 0.41863
YCK3 DNF1 0.40931
YCK3 BSD2 0.40222
YCK3 SWI5 0.39477

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:




External information about YER123W

Other databases:

Visit YER123W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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