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Yeast Fitness
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YER114C / BOI2



Section 1: Phenotypes.
Gene-drug relationships for YER114C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER114C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for BOI2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 7.63658 5.2872e-09
dihydromotuporamine C 15 uM 5.40637 3.0448e-06
itraconazole 17.7 uM 5.31584 1.435e-06
trichostatin A 3.91 uM 4.77933 1.885e-05
propiomazine maleate 500 uM 4.51857 2.0969e-05
nacl 700 mM 4.47612 4.5212e-05
5-fluorouracil 125 uM 3.89594 0.0001543
methotrexate 250 uM 3.85417 0.00017568
promazine hydrochloride 125 uM 3.70934 0.00027423
nitromide 1000 uM 3.61486 0.00036517

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for BOI2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
l-dopa 12.5 ug/ml 19.4032 < 1e-12
wiskostatin 29 uM 13.2686 < 1e-12
nocodazole 10 ug/ml 9.22925 1.5119e-08
zncl2 1875 uM 8.18076 7.6281e-10
licl 150 mM 7.72541 2.7558e-09
licl 150 mM 7.20147 1.243e-08
sorbitol 1.5e+06 uM 6.45919 3.8059e-07
rapamycin 6 nM 6.09899 3.2043e-07
mitomycin c 1000 uM 5.93101 1.4709e-06
nacl 1000 uM 5.0317 0.00025642

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YER114C

Top 10 functional gene interactors with YER114C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with BOI2 by heterozygous co-sensitivity:

Query Interactor Correlation
BOI2 SPI1 0.63242
BOI2 YER119C-A 0.62168
BOI2 ADK2 0.57372
BOI2 ALK2 0.5648
BOI2 ISC10 0.56064
BOI2 FET3 0.54875
BOI2 FMP10 0.54618
BOI2 AVT6 0.54425
BOI2 ECM32 0.542
BOI2 FAU1 0.54118

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with BOI2 by homozygous co-sensitivity:

Query Interactor Correlation
BOI2 YBR204C 0.60144
BOI2 SPS2 0.59347
BOI2 SWE1 0.50379
BOI2 SPR6 0.50085
BOI2 YOL048C 0.50045
BOI2 SUC2 0.48996
BOI2 SWH1_p 0.48481
BOI2 DAL3 0.48171
BOI2 TOM71 0.48105
BOI2 HFD1 0.48057

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YER114C

Other databases:

Visit YER114C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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