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Yeast Fitness
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YER109C / FLO8



Section 1: Phenotypes.
Gene-drug relationships for YER109C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER109C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for FLO8 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 18.8448 3.8753e-06
no drug minimal media 0 18.7565 3.9663e-06
no drug minimal media 0 18.482 4.2658e-06
fk506 50 uM 17.0131 < 1e-12
wiskostatin 29 uM 16.3473 < 1e-12
ID 693632 62.5 uM 15.9679 < 1e-12
no drug minimal media 0 14.1679 3.8623e-06
fk506 100 uM 13.5993 < 1e-12
cantharidin 200 uM 11.9743 < 1e-12
ro 106-9920 (Calbio) 125 uM 11.6153 < 1e-12

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for FLO8 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nocodazole 10 ug/ml 13.8121 2.542e-11
mncl2 2 mM 10.0555 5.0606e-12
fk506 0.05 ug/ml 9.12335 5.7901e-11
nocodazole 10 ug/ml 8.46242 5.4545e-08
licl 100 mM 6.19616 3.7801e-06
l-dopa 12.5 ug/ml 4.35975 5.7096e-05
cantharidin analog 250 ug/ml 3.5109 0.00064094
fk506 0.1 ug/ml 3.36921 0.00094401
mncl2 1 mM 3.08242 0.0020277
bleomycin 1.13 ug/ml 2.9281 0.0044914

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YER109C

Top 10 functional gene interactors with YER109C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with FLO8 by heterozygous co-sensitivity:

Query Interactor Correlation
FLO8 STB2 0.39065
FLO8 YBL044W 0.35238
FLO8 SNF12 0.34813
FLO8 SHO1 0.33956
FLO8 MAK32 0.3375
FLO8 RER1 0.33727
FLO8 YJL175W 0.32262
FLO8 YCL013W_d 0.31058
FLO8 NEJ1 0.30911
FLO8 ADP1 0.30773

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with FLO8 by homozygous co-sensitivity:

Query Interactor Correlation
FLO8 YMR018W 0.7173
FLO8 GDE1 0.68524
FLO8 YER187W 0.67698
FLO8 USA1 0.6734
FLO8 ALD4 0.67158
FLO8 HOS3 0.66474
FLO8 YAT1 0.65637
FLO8 YER184C 0.65192
FLO8 GIP4 0.64771
FLO8 DOT5 0.64643

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YER109C

Other databases:

Visit YER109C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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