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Yeast Fitness
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YER103W / SSA4



Section 1: Phenotypes.
Gene-drug relationships for YER103W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER103W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SSA4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
itraconazole 17.7 uM 3.96437 0.00012459
methotrexate 500 uM 3.50087 0.00069472
fk506 0.1 ug/ml 3.20173 0.0015413
dna protein kinase inhibitor 0 3.14668 0.0017795
mechlorethamine 62.5 uM 3.11544 0.0015638
resveratrol 2000 uM 3.11273 0.0019436
lovastatin 62.5 uM 3.06847 0.0017829
acriflavinium hydrochloride 250 uM 3.0117 0.0020863
amphotericin b 0.31 uM 3.00769 0.0021095
fk506 0.1 ug/ml 2.93442 0.0030684

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SSA4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nocodazole 10 ug/ml 11.3577 6.0858e-10
licl 150 mM 5.50964 1.869e-06
synthetic complete for BY4743 0 5.40414 0.0062109
wiskostatin 29 uM 4.99854 8.6264e-06
licl 100 mM 4.95105 5.1615e-05
fk506 0.1 ug/ml 4.62727 2.5995e-05
ph4 8 4.32767 6.2708e-05
ph4 8 4.19451 9.2397e-05
latrunculin 0.975 uM 4.15428 0.00010382
fk506 0.05 ug/ml 4.084 0.00012718

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YER103W

Top 10 functional gene interactors with YER103W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SSA4 by heterozygous co-sensitivity:

Query Interactor Correlation
SSA4 SPI1 0.59499
SSA4 IVY1 0.57111
SSA4 FET3 0.56029
SSA4 YNL205C 0.54574
SSA4 YMR057C 0.54111
SSA4 NIF3 0.53007
SSA4 ADK2 0.52956
SSA4 BOI2 0.52643
SSA4 YER130C 0.52061
SSA4 YER119C-A 0.5105

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SSA4 by homozygous co-sensitivity:

Query Interactor Correlation
SSA4 HUL4 0.59431
SSA4 UBP9 0.50105
SSA4 SIL1 0.49914
SSA4 AST2 0.49441
SSA4 MOH1 0.48754
SSA4 YMR155W 0.48427
SSA4 PAA1 0.47661
SSA4 PET18 0.47404
SSA4 YOL048C 0.47239
SSA4 YNL195C 0.47224

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YER103W

Other databases:

Visit YER103W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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