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Yeast Fitness
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YER089C / PTC2



Section 1: Phenotypes.
Gene-drug relationships for YER089C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER089C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PTC2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
caspofungin 10 nM 6.18267 7.1168e-08
caspofungin 10 nM 6.17434 7.3269e-08
tunicamycin 0.15 uM 4.74125 0.0025722
acriflavinium hydrochloride 250 uM 4.00516 0.00010961
methotrexate 500 uM 3.73036 0.0003711
wiskostatin 29 uM 3.7123 0.00039004
floxuridine 80000 uM 3.46253 0.00057536
fenbendazole 500 uM 3.4589 0.00058158
acriflavinium hydrochloride 250 uM 3.36952 0.000756
telomerase inhibitor ix (Biomol) 500 uM 3.36015 0.0010138

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for PTC2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mncl2 2 mM 10.6453 < 1e-12
mitomycin c 1000 uM 10.3172 2.606e-12
wiskostatin 29 uM 10.1419 4.0611e-12
mechlorethamine 62.5 uM 8.07174 0.007502
mechlorethamine 62.5 uM 7.81418 0.0079927
mncl2 1 mM 7.45883 5.9094e-09
mechlorethamine 62.5 uM 7.30393 0.009117
mechlorethamine 62.5 uM 6.10491 0.0044154
mncl2 1 mM 5.9928 4.3997e-07
synthetic complete for BY4743 0 5.91824 0.013692

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YER089C

Top 10 functional gene interactors with YER089C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with PTC2 by heterozygous co-sensitivity:

Query Interactor Correlation
PTC2 PPH3 0.41815
PTC2 PMT3 0.35989
PTC2 MSC3 0.35422
PTC2 SLI1 0.34488
PTC2 ACF2 0.3407
PTC2 VTC2 0.33655
PTC2 YLR253W 0.33407
PTC2 YSR3 0.33262
PTC2 PPZ2 0.33179
PTC2 YIL163C 0.32893

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with PTC2 by homozygous co-sensitivity:

Query Interactor Correlation
PTC2 PCL7 0.6537
PTC2 YLR414C 0.63248
PTC2 JEM1 0.60128
PTC2 YJL150W 0.5809
PTC2 MCM16 0.57101
PTC2 MNR2 0.56859
PTC2 PPH3 0.56162
PTC2 IRC16 0.55442
PTC2 CMK2 0.55367
PTC2 SAK1 0.55291

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None




External information about YER089C

Other databases:

Visit YER089C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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