Retrieving results for YER070W, please wait...

Yeast Fitness
Database

Quick Search

Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  
Advanced search

YER070W / RNR1



Section 1: Phenotypes.
Gene-drug relationships for YER070W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER070W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RNR1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
caspofungin 10 nM 5.16653 2.39e-06
bithionol 75 uM 5.1613 2.4329e-06
hydroxyurea 100000 uM 5.1194 2.8058e-06
caspofungin 10 nM 4.97522 4.5734e-06
licl 150 mM 4.62645 2.9327e-05
clotrimazole 1 uM 4.33737 3.7893e-05
metergoline 250 uM 3.77726 0.00022275
caspofungin 10 nM 3.76479 0.00023144
tryptanthrin 250 uM 3.13811 0.0018196
oxethazine 250 uM 3.13247 0.0014908

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RNR1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
bleomycin 1.7 ug/ml 3.37455 0.0016882
latrunculin 0.78 uM 3.29717 0.0020031
potassium disulfite 2500 uM 2.94756 0.0043061
bleomycin 1.13 ug/ml 2.32211 0.016077
bleomycin 1.13 ug/ml 1.80283 0.044092
no drug irradiated 0 1.58072 0.065677
angelicin 62.5 uM 1.54576 0.069782
psoralen 0.5 uM 1.49203 0.076505
licl 100 mM 1.47635 0.078565
bleomycin 1.7 ug/ml 1.42828 0.085167

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YER070W

Top 10 functional gene interactors with YER070W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RNR1 by heterozygous co-sensitivity:

Query Interactor Correlation
RNR1 YMR293C 0.64566
RNR1 ERG28 0.64422
RNR1 PET117 0.62966
RNR1 YOR060C 0.62828
RNR1 BUD16 0.62622
RNR1 PEP5 0.62024
RNR1 LIP1 0.61041
RNR1 MTF1 0.60888
RNR1 HSP10 0.60366
RNR1 PRP24 0.59099

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YER070W

Other databases:

Visit YER070W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


Download a plain text version of this page.