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Yeast Fitness
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YER067C-A / YER067C-A



Section 1: Phenotypes.
Gene-drug relationships for YER067C-A
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER067C-A deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YER067C-A Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 6.25 uM 6.33543 4.9506e-06
bithionol 75 uM 5.79479 2.7478e-07
trichostatin A 3.91 uM 5.49635 2.3431e-06
hydroxyurea 25000 uM 4.10932 7.8831e-05
itraconazole 17.7 uM 3.70544 0.0002775
miconazole 100 uM 3.70108 0.00028121
ketoconazole 11.8 uM 3.48137 0.0015412
mycophenolic acid 125 uM 3.4121 0.00066748
dihydromotuporamine C 15 uM 3.3871 0.00094345
miconazole 50 nM 3.17005 0.0040344

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YER067C-A Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
licl 100 mM 18.0899 < 1e-12
licl 150 mM 9.57681 1.7443e-11
licl 150 mM 7.84096 1.9847e-09
nocodazole 10 ug/ml 5.53863 1.4692e-05
thiabendazole 250 uM 5.10248 1.2824e-05
licl 100 mM 4.80194 7.1396e-05
cantharidin 100 uM 3.48167 0.0013315
licl 100 mM 3.24629 0.0022409
latrunculin 3 uM 3.1707 0.0026462
mebendazole 1000 uM 2.48758 0.0098001

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YER067C-A

Top 10 functional gene interactors with YER067C-A. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YER067C-A by heterozygous co-sensitivity:

Query Interactor Correlation
YER067C-A YER084W 0.52853
YER067C-A ECM34 0.47533
YER067C-A ARN2 0.47028
YER067C-A YEN1 0.46937
YER067C-A RKR1 0.46379
YER067C-A YKL030W 0.4573
YER067C-A FCY21 0.4511
YER067C-A YHR022C 0.43758
YER067C-A SSO2 0.43194
YER067C-A MXR1 0.42324

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YER067C-A by homozygous co-sensitivity:

Query Interactor Correlation
YER067C-A YNL303W 0.80987
YER067C-A YOR114W 0.77968
YER067C-A YBR116C 0.77431
YER067C-A BDH1 0.75373
YER067C-A GLO4 0.74081
YER067C-A PRY3 0.73266
YER067C-A SSP2 0.72226
YER067C-A YCL076W 0.68979
YER067C-A YHR113W 0.67863
YER067C-A CTT1 0.67671

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YER067C-A

Other databases:

Visit YER067C-A in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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