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Yeast Fitness
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YER048C / CAJ1



Section 1: Phenotypes.
Gene-drug relationships for YER048C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER048C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CAJ1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 0.2 uM 8.92765 6.4957e-08
atorvastatin 125 uM 4.84871 7.0018e-06
latrunculin 6.25 uM 4.4777 0.00019035
dyclonine 500 uM 4.19123 0.00062563
mycophenolic acid 125 uM 4.09131 8.3473e-05
caspofungin 10 nM 3.98387 0.0001172
miconazole 25 nM 3.86609 0.0001693
metergoline 250 uM 3.633 0.00034572
dyclonine 500 uM 3.63287 0.0017163
miconazole 100 uM 3.4759 0.00055306

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for CAJ1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
licl 100 mM 21.3275 < 1e-12
allyl disulfide 0.06 % 21.0805 < 1e-12
fk506 0.1 ug/ml 16.912 < 1e-12
nystatin 10 uM 14.7584 2.0432e-08
hygromycin 13.75 uM 13.8248 < 1e-12
cuso4 10000 uM 13.457 < 1e-12
rapamycin 6 nM 12.8759 < 1e-12
nystatin 10 uM 12.8195 7.8293e-08
amphotericin b 0.31 uM 12.7969 < 1e-12
fk506 0.05 ug/ml 12.6411 < 1e-12

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YER048C

Top 10 functional gene interactors with YER048C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with CAJ1 by heterozygous co-sensitivity:

Query Interactor Correlation
CAJ1 TIR2 0.50702
CAJ1 YHL045W 0.50471
CAJ1 GUT1 0.49806
CAJ1 YML003W 0.48316
CAJ1 YAR029W 0.47373
CAJ1 PTP3 0.47366
CAJ1 YMR034C 0.4726
CAJ1 YMR278W 0.46721
CAJ1 YMR027W 0.46593
CAJ1 YME2 0.46534

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with CAJ1 by homozygous co-sensitivity:

Query Interactor Correlation
CAJ1 YLR414C 0.57608
CAJ1 YEL007W 0.54716
CAJ1 DYN1 0.54124
CAJ1 RNH70 0.50314
CAJ1 IRC16 0.48242
CAJ1 NPR1 0.47911
CAJ1 SLM2 0.46883
CAJ1 PTC2 0.46489
CAJ1 YCK1 0.45645
CAJ1 YOL019W 0.45422

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YER048C

Other databases:

Visit YER048C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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