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Yeast Fitness
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YER044C-A / MEI4



Section 1: Phenotypes.
Gene-drug relationships for YER044C-A
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YER044C-A deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MEI4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
miconazole 0.2 uM 13.2566 2.3996e-10
trichostatin A 3.91 uM 8.622 3.7382e-10
caspofungin 10 nM 6.87824 6.2549e-09
latrunculin 6.25 uM 4.93289 7.4938e-05
miconazole 25 nM 3.9549 0.00012835
menadione epoxide 62.5 uM 3.40493 0.00089947
5-fluorouridine 47.5 uM 2.97445 0.0023109
terreic acid 1000 uM 2.81391 0.0041505
fusarubin 250 uM 2.56729 0.0075635
bromhexine hydrochloride 500 uM 2.24662 0.014701

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for MEI4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nocodazole 10 ug/ml 15.2135 5.0869e-12
synthetic complete for BY4743 0 13.9453 0.0025514
synthetic complete for BY4743 0 9.66721 0.00010051
mitomycin c 1000 uM 8.85111 2.8209e-08
hydroxyurea 200000 uM 8.18478 8.8384e-08
latrunculin 3 uM 8.0041 1.2165e-07
hydroxyurea 100000 uM 7.38275 3.7707e-07
mms 0.004 % 7.26061 4.7386e-07
carboplatin 15000 uM 5.57633 1.3572e-05
mechlorethamine 62.5 uM 5.30016 0.0065545

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YER044C-A

Top 10 functional gene interactors with YER044C-A. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with MEI4 by heterozygous co-sensitivity:

Query Interactor Correlation
MEI4 VTC1 0.48463
MEI4 ARN2 0.47364
MEI4 VMR1 0.46106
MEI4 YMR196W 0.44143
MEI4 PET127 0.4388
MEI4 YER084W 0.43606
MEI4 ARN1 0.4289
MEI4 MIP6 0.41449
MEI4 SCW4 0.41413
MEI4 YKL222C 0.4129

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with MEI4 by homozygous co-sensitivity:

Query Interactor Correlation
MEI4 PGU1 0.68262
MEI4 YGR291C 0.65113
MEI4 YOR111W 0.64671
MEI4 BZZ1 0.64001
MEI4 YMC1 0.63575
MEI4 YPL230W 0.63093
MEI4 FCY1 0.63066
MEI4 YPL114W 0.63011
MEI4 YAL045C 0.6213
MEI4 ARN1 0.61422

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YER044C-A

Other databases:

Visit YER044C-A in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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