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Yeast Fitness
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YEL065W / SIT1



Section 1: Phenotypes.
Gene-drug relationships for YEL065W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YEL065W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SIT1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
atorvastatin 125 uM 5.81491 2.5623e-07
methotrexate 500 uM 4.84412 0.002349
hydroxyurea 100000 uM 4.2094 5.7261e-05
4-isopropyltropolone 15.63 uM 3.89361 0.0002359
fluconazole 65.3 uM 3.68114 0.0002988
acriflavinium hydrochloride 250 uM 3.27784 0.00098592
tunicamycin 0.15 uM 3.2374 0.011508
no drug minimal media 0 3.227 0.011642
no drug minimal media 0 3.13241 0.010131
5-fluorouridine 23.8 uM 3.12111 0.0015391

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SIT1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
licl 100 mM 6.40019 2.509e-06
thiabendazole 250 uM 5.41172 5.6875e-06
lovastatin 77.2 uM 4.43509 7.4641e-05
wiskostatin 29 uM 4.32081 6.3977e-05
synthetic complete for BY4743 0 3.7732 0.0064901
methotrexate 250 uM 3.32257 0.0013271
thimerosal 125 nM 3.11413 0.0029956
bisphenol s 100 uM 3.03527 0.0027008
sorbitol 1.5e+06 uM 2.9191 0.003578
licl 100 mM 2.83595 0.005479

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YEL065W

Top 10 functional gene interactors with YEL065W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SIT1 by heterozygous co-sensitivity:

Query Interactor Correlation
SIT1 MEU1 0.52154
SIT1 GPB2 0.5178
SIT1 YMR031C 0.51007
SIT1 CAN1 0.50765
SIT1 PCL9 0.4921
SIT1 YEL023C 0.4901
SIT1 AVT2 0.48433
SIT1 AMN1 0.48052
SIT1 FUN30 0.46951
SIT1 MAK10 0.46882

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SIT1 by homozygous co-sensitivity:

Query Interactor Correlation
SIT1 YBR285W 0.52939
SIT1 YFL052W 0.50627
SIT1 GPT2 0.49566
SIT1 YLF2 0.48594
SIT1 VTH1 0.47591
SIT1 YOR041C 0.47309
SIT1 ECM19 0.47281
SIT1 DAL5 0.47193
SIT1 COS1 0.4684
SIT1 DLD3 0.46791

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YEL065W

Other databases:

Visit YEL065W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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