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Yeast Fitness
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YEL051W / VMA8



Section 1: Phenotypes.
Gene-drug relationships for YEL051W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YEL051W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for VMA8 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 8.85233 2.0483e-10
thiabendazole 250 uM 7.66389 4.0762e-10
alverine citrate 500 uM 6.95342 0.010031
acriflavinium hydrochloride 250 uM 6.72765 1.0588e-08
clotrimazole 1 uM 4.49 2.3032e-05
berberine chloride 125 uM 4.45813 2.5567e-05
haloperidol 250 uM 4.43389 0.00040776
5-fluorocytosine 15.6 uM 4.27501 4.6363e-05
methotrexate 500 uM 4.15858 0.00011193
lapachol 500 uM 4.07799 8.7077e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for VMA8 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
rapamycin 9 nM 6.18241 0.012589
latrunculin 0.78 uM 6.11586 0.012854
latrunculin 0.78 uM 5.69314 1.0627e-05
synthetic complete for BY4743 0 5.13176 0.017969
potassium disulfite 2500 uM 4.90573 5.6951e-05
papuamide b 0.7 ug/ml 4.60766 0.00010927
psoralen 0.5 uM 4.26375 0.00023359
2-cyanoethyl acrylate 360000 uM 4.08841 0.00034489
latrunculin 0.78 uM 4.08159 0.00035016
ph4 7.5 3.92138 0.0005003

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YEL051W

Top 10 functional gene interactors with YEL051W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with VMA8 by heterozygous co-sensitivity:

Query Interactor Correlation
VMA8 YLR458W 0.53561
VMA8 PEP5 0.51772
VMA8 BIM1 0.51369
VMA8 ARB1 0.49605
VMA8 BRL1 0.48953
VMA8 PRP16 0.46965
VMA8 RRN9 0.46555
VMA8 YMR293C 0.46264
VMA8 PCM1 0.45886
VMA8 PRP24 0.45699

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YEL051W

Other databases:

Visit YEL051W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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