Retrieving results for YEL045C, please wait...

Yeast Fitness
Database

Quick Search

Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  
Advanced search

YEL045C / YEL045C



Section 1: Phenotypes.
Gene-drug relationships for YEL045C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YEL045C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YEL045C Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
bufexamac 1000 uM 10.3678 < 1e-12
hydroxyurea 100000 uM 7.70597 3.5261e-10
5-fluorouracil 76.8 uM 7.39599 1.0276e-08
methotrexate 250 uM 6.85431 4.6925e-08
5-fluorouridine 95 uM 6.16962 7.4487e-08
helenine 250 uM 6.08414 1.0037e-07
mitomycin c 1000 uM 5.66718 4.277e-07
bithionol 75 uM 5.50631 7.4562e-07
berberine chloride 125 uM 5.32647 1.3837e-06
licl 150 mM 5.27079 4.5188e-06

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YEL045C Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
rapamycin 9 nM 20.7676 0.0011553
latrunculin 0.78 uM 15.1116 0.0021752
potassium disulfite 2500 uM 8.27829 7.504e-08
ph4 7.5 5.16375 3.2613e-05
dmaec 240000 uM 5.05309 4.1387e-05
licl 100 mM 4.47049 0.00014782
bisphenol 125 uM 3.75323 0.00072772
synthetic complete for BY4743 0 3.63088 0.034093
dmaec 240000 uM 3.05207 0.0034307
ph4 7.5 3.02716 0.0036221

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YEL045C

Top 10 functional gene interactors with YEL045C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YEL045C by heterozygous co-sensitivity:

Query Interactor Correlation
YEL045C GLY1 0.55073
YEL045C YMR290W-A 0.54791
YEL045C YDL089W 0.49748
YEL045C DSS1 0.48086
YEL045C ERG28 0.4657
YEL045C CEF1 0.46306
YEL045C CUS1 0.45754
YEL045C SRB4 0.44134
YEL045C PRO3 0.44047
YEL045C ARD1 0.43967

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YEL045C by homozygous co-sensitivity:

Query Interactor Correlation
YEL045C COR1 0.52465
YEL045C UBP15 0.50487
YEL045C SNF5 0.46146
YEL045C BUD21 0.45277
YEL045C YAF9 0.44779
YEL045C VRP1 0.44324
YEL045C SAC1 0.43793
YEL045C MSK1 0.42807
YEL045C GLY1 0.42505
YEL045C IMG1 0.42125

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:




External information about YEL045C

Other databases:

Visit YEL045C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


Download a plain text version of this page.