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YEL039C / CYC7



Section 1: Phenotypes.
Gene-drug relationships for YEL039C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YEL039C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CYC7 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
bufexamac 1000 uM 4.19461 6.004e-05
itraconazole 4.4 uM 3.83992 0.00018361
tunicamycin 0.15 uM 3.57982 0.007939
methotrexate 250 uM 3.35268 0.0010342
itraconazole 17.7 uM 3.30444 0.00091315
latrunculin 3.91 uM 3.23312 0.0014194
5-fluorouracil 76.8 uM 3.22575 0.0014471
5-fluorouridine 95 uM 3.13604 0.0014759
tryptanthrin 250 uM 3.12032 0.0019057
atorvastatin 125 uM 3.10539 0.0016085

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for CYC7 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
licl 100 mM 10.3533 2.6102e-09
synthetic complete for BY4743 0 5.39964 0.016314
mncl2 2 mM 5.06026 7.1749e-06
latrunculin 3 uM 4.42274 0.00016426
licl 150 mM 4.01959 0.00015307
nocodazole 10 ug/ml 3.49199 0.0013013
licl 150 mM 3.47871 0.00070024
mechlorethamine 62.5 uM 3.34073 0.039557
lovastatin 154.5 uM 3.20901 0.0017616
synthetic complete for BY4743 0 3.06538 0.02738

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YEL039C

Top 10 functional gene interactors with YEL039C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with CYC7 by heterozygous co-sensitivity:

Query Interactor Correlation
CYC7 YOL083W 0.63976
CYC7 YOR378W 0.63538
CYC7 RSB1 0.61508
CYC7 ECM40 0.59872
CYC7 VAB2 0.59398
CYC7 GYP6 0.5912
CYC7 FIT2 0.58493
CYC7 TRR2 0.58486
CYC7 YHL005C 0.57928
CYC7 INO1 0.57595

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with CYC7 by homozygous co-sensitivity:

Query Interactor Correlation
CYC7 AFG1 0.70703
CYC7 THI12 0.70246
CYC7 YLR030W 0.68049
CYC7 RNH203 0.64954
CYC7 YIR020C 0.64707
CYC7 YNL194C 0.64638
CYC7 NDJ1 0.64627
CYC7 URH1 0.63689
CYC7 YAR047C 0.63677
CYC7 SPO20 0.62547

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None




External information about YEL039C

Other databases:

Visit YEL039C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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