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Yeast Fitness

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YEL034W / HYP2

Section 1: Phenotypes.
Gene-drug relationships for YEL034W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YEL034W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for HYP2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
caspofungin 10 nM 9.24016 3.5496e-12
caspofungin 10 nM 9.06608 5.0596e-12
caspofungin 10 nM 9.00136 5.8882e-12
fenpropimorph 4.7 uM 8.10605 9.0126e-11
caspofungin 10 nM 6.9819 4.3551e-09
fluconazole 65.3 uM 6.16506 7.5682e-08
daunorubicin 125 uM 5.62109 5.0164e-07
latrunculin 6.25 uM 5.528 2.2937e-05
fenpropimorph 1.65 nM 5.46185 0.0013996
itraconazole 17.7 uM 4.71549 1.0929e-05

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YEL034W

Top 10 functional gene interactors with YEL034W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with HYP2 by heterozygous co-sensitivity:

Query Interactor Correlation
HYP2 UTR5 0.55944
HYP2 YEL033W 0.46308
HYP2 HFI1 0.42264
HYP2 CDC24 0.40538
HYP2 CUP5 0.40299
HYP2 PEP12 0.39231
HYP2 YDL041W 0.38199
HYP2 RHO3 0.36727
HYP2 PHO2 0.34769
HYP2 YLR358C 0.34668

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YEL034W

Other databases:

Visit YEL034W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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