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Yeast Fitness
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YEL011W / GLC3



Section 1: Phenotypes.
Gene-drug relationships for YEL011W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YEL011W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GLC3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
drofenine hydrochloride 750 uM 6.97429 4.4723e-09
clotrimazole 1 uM 6.16076 7.6826e-08
bufexamac 1000 uM 6.00915 1.3036e-07
fluconazole 65.3 uM 5.78183 2.8742e-07
5-fluorouracil 38.5 uM 5.75451 3.16e-07
itraconazole 37.6 uM 5.39897 1.0789e-06
itraconazole 8.8 uM 5.32005 1.4144e-06
fluconazole 130.6 uM 5.28655 1.5864e-06
miconazole 50 nM 5.16705 2.3858e-06
itraconazole 35.4 uM 4.98903 4.365e-06

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for GLC3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 15.8475 0.00027313
mncl2 2 mM 5.89071 5.9701e-07
nocodazole 10 ug/ml 5.48466 1.6463e-05
licl 150 mM 4.92776 1.0653e-05
tryptanthrin 250 uM 4.51185 3.654e-05
synthetic complete for BY4743 0 4.46013 0.0033198
nitric oxide 800 uM 4.27482 0.00011381
methotrexate 250 uM 4.08451 0.00018746
latrunculin 3 uM 3.84849 0.00058854
licl 150 mM 3.76185 0.00031859

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YEL011W

Top 10 functional gene interactors with YEL011W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with GLC3 by heterozygous co-sensitivity:

Query Interactor Correlation
GLC3 YOR041C 0.48874
GLC3 RSF1 0.47162
GLC3 SLK19 0.4467
GLC3 BFA1 0.44559
GLC3 AVT2 0.44401
GLC3 YML018C 0.43364
GLC3 YLR437C 0.41817
GLC3 PCK1 0.41725
GLC3 HAM1 0.41003
GLC3 YJR100C 0.40609

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with GLC3 by homozygous co-sensitivity:

Query Interactor Correlation
GLC3 YLR346C 0.5368
GLC3 PLB2 0.51742
GLC3 MRPL39 0.51195
GLC3 YPL236C 0.51007
GLC3 YOL160W 0.50827
GLC3 SHE3 0.50341
GLC3 FLO8_p 0.50323
GLC3 GDE1 0.50213
GLC3 YFR032C 0.4991
GLC3 FLO8 0.49806

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YEL011W

Other databases:

Visit YEL011W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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