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Yeast Fitness
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YEL009C / GCN4



Section 1: Phenotypes.
Gene-drug relationships for YEL009C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YEL009C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GCN4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 250 uM 14.4337 0.0023829
cantharidin 250 uM 14.0526 0.0025129
cantharidin 250 uM 11.6375 0.0036515
cantharidin 250 uM 11.2457 0.0039074
cantharidin 250 uM 10.1172 0.0048144
alverine citrate 500 uM 9.84675 0.0050784
cantharidin 250 uM 9.46109 0.0054939
alverine citrate 500 uM 7.59958 0.0084389
fenpropimorph 8 nM 4.08006 8.6508e-05
caspofungin 10 nM 3.7239 0.00026231

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for GCN4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 100.952 4.9054e-05
synthetic complete for BY4743 0 80.5331 2.7986e-09
synthetic complete for BY4743 0 77.672 3.3527e-09
synthetic complete for BY4743 0 63.3625 4.3307e-06
synthetic complete for BY4743 0 44.0183 4.0942e-10
synthetic complete for BY4743 0 41.2058 6.4799e-10
synthetic complete for BY4743 0 40.6723 8.4719e-08
synthetic complete for BY4743 0 35.5243 1.6633e-07
synthetic complete for BY4743 0 32.0695 0.00048546
tryptophan dropout 0 29.3628 2.4498e-11

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YEL009C

Top 10 functional gene interactors with YEL009C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with GCN4 by heterozygous co-sensitivity:

Query Interactor Correlation
GCN4 GPB2 0.67032
GCN4 YMR041C 0.65012
GCN4 SRC1 0.637
GCN4 YPL260W 0.62088
GCN4 GDA1 0.60011
GCN4 YAL066W 0.59868
GCN4 YMR031C 0.59052
GCN4 YBL048W 0.57282
GCN4 YNL155W 0.56201
GCN4 YJL152W 0.55739

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with GCN4 by homozygous co-sensitivity:

Query Interactor Correlation
GCN4 GCN2 0.76732
GCN4 GCN3 0.76162
GCN4 TRP3 0.64022
GCN4 TRP1 0.60446
GCN4 GCN20 0.58791
GCN4 YDR008C 0.53498
GCN4 TRP2 0.53276
GCN4 UPC2 0.53034
GCN4 YGL117W 0.50718
GCN4 TKL1 0.48963

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None




External information about YEL009C

Other databases:

Visit YEL009C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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