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Yeast Fitness

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YEL002C / WBP1

Section 1: Phenotypes.
Gene-drug relationships for YEL002C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YEL002C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for WBP1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 8.5757 4.2222e-10
methotrexate 500 uM 8.4837 5.3822e-10
caspofungin 10 nM 5.49367 7.7882e-07
drofenine hydrochloride 750 uM 5.42814 9.7594e-07
distamycin a 250 uM 4.70438 2.3415e-05
5-fluorouridine 95 uM 4.02198 0.00010395
clozapine 500 uM 3.66511 0.00031371
dyclonine 500 uM 3.56527 0.001943
hydroxyurea 100000 uM 3.51643 0.00049039
hydroxyurea 50000 uM 3.30426 0.00091364

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YEL002C

Top 10 functional gene interactors with YEL002C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with WBP1 by heterozygous co-sensitivity:

Query Interactor Correlation
WBP1 PMI40 0.44365
WBP1 GAB1 0.41225
WBP1 JNM1 0.4012
WBP1 SGO1 0.39728
WBP1 SIT1 0.39701
WBP1 IES6 0.38462
WBP1 MRE11 0.38309
WBP1 YEL023C 0.3814
WBP1 TUS1 0.37576
WBP1 PET111 0.37545

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YEL002C

Other databases:

Visit YEL002C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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