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Yeast Fitness
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YDR432W / NPL3



Section 1: Phenotypes.
Gene-drug relationships for YDR432W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR432W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for NPL3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 7.25219 1.5333e-08
fenpropimorph 4.7 uM 6.98922 4.2452e-09
itraconazole 17.7 uM 6.79065 8.495e-09
itraconazole 8.8 uM 5.32717 1.3803e-06
itraconazole 8.8 uM 4.54198 1.9415e-05
no drug minimal media 0 4.54152 0.0019635
latrunculin 1.95 uM 4.52411 3.9385e-05
itraconazole 8.8 uM 4.50374 2.2016e-05
5-fluorocytosine 15.6 uM 4.48971 2.3054e-05
no drug minimal media 0 4.10591 0.0046505

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for NPL3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 12.4258 1.4364e-10
rapamycin 9 nM 10.2535 0.004689
angelicin 62.5 uM 7.27093 4.6476e-07
psoralen 0.5 uM 6.34359 2.8096e-06
ph4 7.5 5.47406 1.6836e-05
synthetic complete for BY4743 0 5.24104 0.00059895
synthetic complete for BY4743 0 5.05256 0.0019624
latrunculin 0.78 uM 5.01712 4.4732e-05
aureobasidin a 0.02 ug/ml 4.75826 7.8544e-05
synthetic complete for BY4743 0 4.59289 0.0012526

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR432W

Top 10 functional gene interactors with YDR432W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with NPL3 by heterozygous co-sensitivity:

Query Interactor Correlation
NPL3 RPG1 0.55087
NPL3 APC4 0.54564
NPL3 SWF1 0.53586
NPL3 MTQ2 0.50598
NPL3 RRN5 0.49403
NPL3 YIP1 0.494
NPL3 MSS51 0.49075
NPL3 RGP1 0.4807
NPL3 CWC25 0.47998
NPL3 VRP1 0.47738

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YDR432W

Other databases:

Visit YDR432W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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