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Yeast Fitness
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YDR382W / RPP2B



Section 1: Phenotypes.
Gene-drug relationships for YDR382W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR382W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPP2B Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 3.27419 0.0023859
lovastatin 62.5 uM 3.17134 0.001336
itraconazole 4.4 uM 3.10741 0.0015994
5-fluorouracil 38.5 uM 2.97262 0.0044888
fenpropimorph 2.3 uM 2.55938 0.0068819
floxuridine 3.37 uM 2.32338 0.01683
fenpropimorph 4.7 uM 2.1968 0.016501
5-fluorouracil 19.2 uM 1.93305 0.035563
ID 604586 31.25 uM 1.88432 0.034317
methotrexate 125 uM 1.8826 0.034437

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPP2B Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 4.7918 7.2993e-05
licl 100 mM 4.4001 0.00017269
rapamycin 9 nM 2.70767 0.056809
bisphenol 125 uM 1.43333 0.084453
carboplatin 700 uM 1.37251 0.093383
dmaec 240000 uM 1.0234 0.15984
latrunculin 0.78 uM 0.971702 0.17204
licl 100 mM 0.958766 0.17519
benzaldehyde 0.003 % 0.742839 0.23358
thimerosal 125 nM 0.660476 0.25866

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR382W

Top 10 functional gene interactors with YDR382W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPP2B by heterozygous co-sensitivity:

Query Interactor Correlation
RPP2B RPL6A 0.48398
RPP2B YBR190W 0.46909
RPP2B REI1 0.4518
RPP2B TIF6 0.44973
RPP2B RPP1A 0.44506
RPP2B RPL22A 0.43613
RPP2B RPL5 0.43337
RPP2B BUD28 0.42527
RPP2B RPL37A 0.42495
RPP2B RPL12A 0.42384

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YDR382W

Other databases:

Visit YDR382W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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