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Yeast Fitness

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YDR353W / TRR1

Section 1: Phenotypes.
Gene-drug relationships for YDR353W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR353W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for TRR1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 8.6271 3.6884e-10
itraconazole 8.8 uM 5.70506 3.751e-07
amphotericin b 0.62 uM 5.40717 1.0489e-06
haloperidol 250 uM 5.12942 0.00012467
fenpropimorph 1.2 uM 4.53147 2.0098e-05
itraconazole 8.8 uM 4.30782 4.17e-05
methotrexate 500 uM 4.12198 0.00012415
amphotericin b 0.31 uM 3.73423 0.00025415
itraconazole 8.8 uM 3.71405 0.00027032
itraconazole 4.4 uM 3.61399 0.00036614

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YDR353W

Top 10 functional gene interactors with YDR353W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with TRR1 by heterozygous co-sensitivity:

Query Interactor Correlation
TRR1 BOS1 0.46
TRR1 ALG7 0.43305
TRR1 YKE2 0.42857
TRR1 GPI17 0.42287
TRR1 DCS1 0.42144
TRR1 CDC34 0.38815
TRR1 FLX1 0.38428
TRR1 MSM1 0.38146
TRR1 YDL196W 0.37829
TRR1 SCM3 0.37729

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YDR353W

Other databases:

Visit YDR353W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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