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Yeast Fitness
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YDR329C / PEX3



Section 1: Phenotypes.
Gene-drug relationships for YDR329C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR329C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PEX3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 7.92656 3.1245e-07
dna protein kinase inhibitor 0 6.49062 1.3215e-07
alverine citrate 500 uM 5.61661 0.015134
alverine citrate 500 uM 5.25684 0.017167
fluconazole 65.3 uM 5.00509 4.1343e-06
nocodazole 2 ug/ml 4.93633 5.2147e-06
econazole nitrate 0.24 uM 4.69045 1.1879e-05
clozapine 500 uM 4.66527 1.2916e-05
wiskostatin 29 uM 4.45191 4.8466e-05
miconazole 100 uM 4.17486 6.396e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for PEX3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mms 0.002 % 16.8014 0.0017619
phosphatase inhibitor 3 uM 9.33011 3.3394e-11
wiskostatin 29 uM 8.80736 1.3571e-10
fk506 100 uM 7.12958 1.5317e-08
fk506 200 uM 6.93916 2.6697e-08
mms 0.002 % 6.91669 2.8512e-08
allyl disulfide 0.06 % 6.82018 3.7839e-08
sodium sulfate 625 uM 6.43786 1.1694e-07
myriocin 0.2 ug/ml 5.71894 1.0071e-05
fk506 50 uM 5.56901 1.5644e-06

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR329C

Top 10 functional gene interactors with YDR329C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with PEX3 by heterozygous co-sensitivity:

Query Interactor Correlation
PEX3 SKI7 0.40902
PEX3 TRS23 0.3749
PEX3 GPI8 0.37487
PEX3 TPP1 0.36003
PEX3 FBP26 0.35404
PEX3 MET6 0.3501
PEX3 OPI1 0.34739
PEX3 YJR115W 0.34708
PEX3 ILV1 0.34663
PEX3 ICL1 0.34524

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with PEX3 by homozygous co-sensitivity:

Query Interactor Correlation
PEX3 PEX19 0.77425
PEX3 PEX14 0.72255
PEX3 PEX4 0.71641
PEX3 PEX13 0.71396
PEX3 YGL152C 0.70154
PEX3 YJL211C 0.69516
PEX3 PEX17 0.69391
PEX3 PEX22 0.66635
PEX3 PEX8 0.64511
PEX3 PEX10 0.63857

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YDR329C

Other databases:

Visit YDR329C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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