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Yeast Fitness
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YDR285W / ZIP1



Section 1: Phenotypes.
Gene-drug relationships for YDR285W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR285W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ZIP1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 250 uM 4.75204 2.0399e-05
dmso 4% 4 uM 4.12441 7.5136e-05
dihydromotuporamine C 15 uM 3.84626 0.00026917
5-fluorouracil 19.2 uM 3.77105 0.0008359
methotrexate 500 uM 3.677 0.00042981
dna protein kinase inhibitor 0 3.67209 0.00043564
haloperidol 250 uM 3.51998 0.0021118
methotrexate 125 uM 3.23871 0.0013986
5-fluorouridine 23.8 uM 3.22488 0.0011475
econazole 0.12 uM 3.1877 0.0012755

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ZIP1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 0.78 uM 31.3123 0.00050919
rapamycin 9 nM 15.4159 0.0020908
synthetic complete for BY4743 0 13.3022 0.0028019
synthetic complete for BY4743 0 10.2132 0.0047256
latrunculin 0.78 uM 6.97472 0.0099718
nocodazole 10 ug/ml 6.52665 1.9516e-06
mechlorethamine 62.5 uM 6.01784 0.01326
cantharidin 200 uM 4.72184 1.9648e-05
mitomycin c 1 mM 4.47303 0.00014699
methotrexate 250 uM 4.06905 0.00019519

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR285W

Top 10 functional gene interactors with YDR285W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ZIP1 by heterozygous co-sensitivity:

Query Interactor Correlation
ZIP1 YHL008C 0.4722
ZIP1 RAD16 0.45367
ZIP1 TPS3 0.42991
ZIP1 SIP18 0.41991
ZIP1 ECM7 0.41556
ZIP1 YMR141C 0.39384
ZIP1 GIC2 0.39297
ZIP1 YIM1 0.38875
ZIP1 RNY1 0.38444
ZIP1 YDR278C 0.38349

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with ZIP1 by homozygous co-sensitivity:

Query Interactor Correlation
ZIP1 SUL2 0.58124
ZIP1 YDR248C 0.4926
ZIP1 YDR336W 0.49259
ZIP1 YOR129C 0.48896
ZIP1 YDR179W-A 0.48594
ZIP1 ROM1 0.48139
ZIP1 PPN1 0.47972
ZIP1 NYV1 0.47325
ZIP1 YPL035C 0.47062
ZIP1 MET8 0.46352

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YDR285W

Other databases:

Visit YDR285W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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