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Yeast Fitness
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YDR256C / CTA1



Section 1: Phenotypes.
Gene-drug relationships for YDR256C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR256C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CTA1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
lapachol 1000 uM 9.76916 < 1e-12
alverine citrate 500 uM 8.42766 0.0068945
trichlormethine 1000 uM 6.77499 8.9733e-09
itraconazole 4.4 uM 6.07 1.0545e-07
no drug minimal media 0 5.16963 0.001778
latrunculin 3.91 uM 5.16446 6.1583e-06
alverine citrate 500 uM 5.0879 0.018263
no drug minimal media 0 4.93837 0.0021641
clozapine 500 uM 4.79093 8.4971e-06
dihydromotuporamine C 15 uM 4.51469 4.0467e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for CTA1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 0.78 uM 10.0708 0.0048582
rapamycin 9 nM 8.14826 0.0073648
sorbitol 1.5e+06 uM 7.59122 2.3309e-08
rapamycin 9 nM 7.53875 0.0085721
synthetic complete for BY4743 0 7.37203 1.1958e-05
rapamycin 9 nM 5.8693 0.0049324
minimal media 0 4.78286 2.9808e-05
synthetic complete for BY4743 0 4.74042 0.00039581
ph8 0 4.43841 7.3991e-05
myriocin 0.2 ug/ml 4.40175 0.00017206

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR256C

Top 10 functional gene interactors with YDR256C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with CTA1 by heterozygous co-sensitivity:

Query Interactor Correlation
CTA1 CSM4 0.40101
CTA1 HUA1 0.38837
CTA1 BTT1 0.38048
CTA1 ERP4 0.37666
CTA1 YDR282C 0.37244
CTA1 DSK2 0.37201
CTA1 YMR086W 0.37085
CTA1 IRC12 0.367
CTA1 YDR262W 0.36588
CTA1 FIR1 0.36144

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with CTA1 by homozygous co-sensitivity:

Query Interactor Correlation
CTA1 PUT2 0.58964
CTA1 YGR201C 0.57483
CTA1 PUS2 0.56288
CTA1 YML018C 0.55896
CTA1 YDR319C 0.55445
CTA1 YMR262W 0.54449
CTA1 LYS12 0.53643
CTA1 LHP1 0.53217
CTA1 YPR059C 0.52927
CTA1 HBT1 0.51763

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YDR256C

Other databases:

Visit YDR256C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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