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Yeast Fitness

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YDR232W / HEM1

Section 1: Phenotypes.
Gene-drug relationships for YDR232W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR232W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for HEM1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ferulic acid 3.95 uM 6.77598 5.859e-08
fluconazole 65.3 uM 6.21792 6.2925e-08
bufexamac 1000 uM 6.04098 1.1667e-07
bufexamac 1000 uM 5.97872 1.4494e-07
resveratrol 2000 uM 5.96557 5.996e-07
thiabendazole 500 uM 5.72144 3.544e-07
fluconazole 65.3 uM 5.42727 9.7887e-07
pyrimethamine 1000 uM 4.76852 9.158e-06
wiskostatin 29 uM 4.65769 2.6797e-05
cloxyquin 15.6 uM 4.41618 2.9324e-05

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YDR232W

Top 10 functional gene interactors with YDR232W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with HEM1 by heterozygous co-sensitivity:

Query Interactor Correlation
HEM1 TAF10 0.619
HEM1 RAI1 0.59208
HEM1 SEC9 0.57769
HEM1 ARG82 0.55831
HEM1 SPC19 0.54296
HEM1 JJJ1 0.54263
HEM1 SGF73 0.53528
HEM1 GDI1 0.52925
HEM1 RAD27 0.52918
HEM1 CPR7 0.52607

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YDR232W

Other databases:

Visit YDR232W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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