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YDR217C / RAD9



Section 1: Phenotypes.
Gene-drug relationships for YDR217C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR217C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RAD9 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorouracil 38.4 uM 3.40082 0.00090942
no drug minimal media 0 3.3852 0.0097816
sulfanilamide 62.5 uM 3.1309 0.0014974
methotrexate 500 uM 3.06031 0.0022253
alverine citrate 500 uM 3.03092 0.0019785
methotrexate 250 uM 3.00119 0.0025895
dyclonine 500 uM 2.9705 0.0058451
clozapine 500 uM 2.91931 0.0026852
mecysteine hydrochloride 62.5 uM 2.9053 0.0027889
methotrexate 125 uM 2.79832 0.0043142

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RAD9 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mechlorethamine 62.5 uM 60.0574 0.00013857
mechlorethamine 62.5 uM 56.1097 0.00015874
mechlorethamine 62.5 uM 53.5457 0.0001743
mechlorethamine 62.5 uM 41.7734 0.00028628
mechlorethamine 62.5 uM 41.2848 0.00029309
mechlorethamine 62.5 uM 35.3916 0.0003987
mechlorethamine 62.5 uM 34.2415 2.7381e-05
mitomycin c 1000 uM 31.3506 < 1e-12
mechlorethamine 62.5 uM 30.9499 3.7054e-05
mechlorethamine 62.5 uM 29.1503 4.4328e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR217C

Top 10 functional gene interactors with YDR217C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RAD9 by heterozygous co-sensitivity:

Query Interactor Correlation
RAD9 STE13 0.82319
RAD9 YKL044W 0.78067
RAD9 YKL171W 0.77528
RAD9 YPL197C 0.77072
RAD9 YDR157W 0.77067
RAD9 OST5 0.76163
RAD9 YPR116W 0.74802
RAD9 YOL013W-A 0.73204
RAD9 FRT2 0.7307
RAD9 TRR2 0.72947

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with RAD9 by homozygous co-sensitivity:

Query Interactor Correlation
RAD9 MEC3 0.77305
RAD9 RAD17 0.76145
RAD9 RAD1 0.72624
RAD9 RAD10 0.72535
RAD9 PSO2 0.72185
RAD9 RAD4 0.70521
RAD9 RAD14 0.70092
RAD9 RAD2 0.68596
RAD9 RAD24 0.67916
RAD9 MUS81 0.65076

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YDR217C

Other databases:

Visit YDR217C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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