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Yeast Fitness
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YDR207C / UME6



Section 1: Phenotypes.
Gene-drug relationships for YDR207C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR207C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for UME6 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dmso 4% 4 uM 6.32947 4.2614e-08
clozapine 125 uM 6.08867 9.88e-08
dyclonine 500 uM 3.84551 0.0011645
5-fluorouracil 19.2 uM 3.43489 0.00082998
fk506 0.1 ug/ml 3.39629 0.00092052
fk506 0.1 ug/ml 3.29462 0.0012067
methotrexate 125 uM 2.66205 0.0060241
quinacrine hydrochloride 1000 uM 2.66051 0.00532
latrunculin 2.8 uM 1.7107 0.046865
daunorubicin 125 uM 1.63663 0.054194

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for UME6 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mechlorethamine 62.5 uM 14.0656 0.00038915
rapamycin 9 nM 11.0291 0.0007982
mechlorethamine 62.5 uM 10.6912 0.00087469
mechlorethamine 62.5 uM 10.1377 0.0010224
rapamycin 9 nM 9.63559 0.0052999
latrunculin 0.78 uM 8.01206 0.0020294
licl 100 mM 7.3332 4.1359e-07
benomyl 10 ug/ml 6.65866 0.0034522
mechlorethamine 62.5 uM 5.82727 0.014104
psoralen 0.5 uM 5.45703 1.7453e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR207C

Top 10 functional gene interactors with YDR207C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with UME6 by heterozygous co-sensitivity:

Query Interactor Correlation
UME6 MRPL38 0.70452
UME6 BRF1 0.68751
UME6 VAS1 0.68701
UME6 SRP54 0.66504
UME6 SFT1 0.63661
UME6 BUD26 0.61406
UME6 ERD2 0.60793
UME6 HES1 0.57944
UME6 SDA1 0.5754
UME6 MCD4 0.57086

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with UME6 by homozygous co-sensitivity:

Query Interactor Correlation
UME6 AEP2 0.49677
UME6 SSQ1 0.46719
UME6 FZO1 0.43083
UME6 YER087W 0.41682
UME6 YDR115W 0.38968
UME6 HUR1 0.38004
UME6 RAD50 0.3792
UME6 GDH3 0.37153
UME6 YNR036C 0.36121
UME6 MRPS28 0.34392

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YDR207C

Other databases:

Visit YDR207C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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