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Yeast Fitness
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YDR195W / REF2



Section 1: Phenotypes.
Gene-drug relationships for YDR195W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR195W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for REF2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
alverine citrate 500 uM 7.28058 0.0091739
methotrexate 500 uM 5.69685 1.3076e-06
methotrexate 500 uM 5.62875 1.594e-06
cantharidin 250 uM 5.15672 0.017805
cantharidin 200 uM 5.05732 8.4107e-06
cantharidin 250 uM 4.62707 0.021835
cantharidin 250 uM 4.6141 0.02195
thiabendazole 500 uM 4.58709 1.6731e-05
cantharidin 250 uM 4.46226 0.023365
dyclonine 500 uM 4.13699 0.0006891

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for REF2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 15.0989 0.00031535
latrunculin 0.78 uM 9.06785 1.9689e-08
potassium disulfite 2500 uM 8.2771 7.5195e-08
synthetic complete for BY4743 0 6.25949 0.00021014
latrunculin 0.78 uM 5.9614 6.0991e-06
licl 100 mM 5.29226 2.4769e-05
licl 100 mM 5.10782 3.6781e-05
synthetic complete for BY4743 0 5.10593 0.0018757
synthetic complete for BY4743 0 4.69501 0.0026805
papuamide b 0.7 ug/ml 4.40494 0.00017086

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR195W

Top 10 functional gene interactors with YDR195W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with REF2 by heterozygous co-sensitivity:

Query Interactor Correlation
REF2 YNL228W 0.6223
REF2 POP8 0.61696
REF2 BRR2 0.61461
REF2 DUO1 0.6008
REF2 SCC2 0.59398
REF2 NPT1 0.59322
REF2 NCS6 0.59191
REF2 SPP2 0.59155
REF2 CCA1 0.59025
REF2 ILS1 0.57714

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YDR195W

Other databases:

Visit YDR195W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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