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YDR171W / HSP42



Section 1: Phenotypes.
Gene-drug relationships for YDR171W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR171W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for HSP42 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nocodazole 2 ug/ml 3.28261 0.0009725
alverine citrate 500 uM 3.2186 0.0036868
miconazole 0.2 uM 2.74564 0.0071811
ketoconazole 11.8 uM 2.59339 0.0098011
nocodazole 6.9 uM 1.94828 0.054455
quinacrine hydrochloride 1000 uM 1.83824 0.036176
5-fluorouracil 125 uM 1.83057 0.036754
benomyl 13.8 uM 1.7961 0.066211
benomyl 6.9 uM 1.72122 0.072916
methotrexate 125 uM 1.66818 0.050965

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for HSP42 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
23 degrees C 0 5.96925 6.8823e-05
nacl 1000 uM 4.67838 0.00043482
nacl 1000 uM 4.17616 0.00094964
5-fluorouracil 19.2 uM 2.52077 0.015174
nystatin 10 uM 2.43967 0.017434
synthetic complete for BY4743 0 2.25837 0.02375
sorbitol 1.5e+06 uM 2.07525 0.032356
nystatin 10 uM 2.02836 0.034998
sorbitol 1.5e+06 uM 1.96269 0.030233
ph8 0 1.91233 0.033456

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR171W

Top 10 functional gene interactors with YDR171W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with HSP42 by heterozygous co-sensitivity:

Query Interactor Correlation
HSP42 GTS1 0.66637
HSP42 RPL22B 0.66519
HSP42 YGR021W 0.61857
HSP42 ADH7 0.61617
HSP42 FZF1 0.60352
HSP42 PCP1 0.60158
HSP42 RCK1 0.58966
HSP42 YKL037W 0.58814
HSP42 ARR2 0.57568
HSP42 YPT52 0.5709

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with HSP42 by homozygous co-sensitivity:

Query Interactor Correlation
HSP42 MEP1 0.72916
HSP42 YOR129C 0.68387
HSP42 YOR225W 0.67335
HSP42 YMR259C 0.6453
HSP42 SPR3 0.64076
HSP42 NRK1 0.63054
HSP42 TFS1 0.62938
HSP42 LAP4 0.62514
HSP42 GAL2 0.61768
HSP42 CWP1 0.61508

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YDR171W

Other databases:

Visit YDR171W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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