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YDR146C / SWI5



Section 1: Phenotypes.
Gene-drug relationships for YDR146C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR146C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SWI5 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
itraconazole 8.8 uM 6.79926 8.2432e-09
caspofungin 10 nM 4.8218 7.6628e-06
caspofungin 10 nM 4.7119 1.1061e-05
mechlorethamine 500 uM 3.81649 0.00019739
5-fluorouracil 19.2 uM 3.71838 0.00093421
mechlorethamine 500 uM 3.69025 0.00029064
fluconazole 31.25 uM 3.44754 0.0006014
cantharidin 250 uM 3.19104 0.04288
fk506 0.1 ug/ml 3.14411 0.0017915
5-fluorocytosine 15.6 uM 3.06278 0.0018114

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SWI5 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 14.5164 0.0003544
nocodazole 10 ug/ml 9.81745 5.9248e-09
mitomycin c 1000 uM 7.30207 4.6868e-08
parthenolide 1000 uM 5.74867 2.3597e-06
latrunculin 3 uM 5.21236 2.9383e-05
cantharidin analog 250 ug/ml 4.92727 1.0669e-05
papuamide b 0.7 ug/ml 4.73708 8.2268e-05
papuamide b 0.7 ug/ml 4.65729 2.3787e-05
papuamide b 1 ug/ml 4.57532 3.0306e-05
wiskostatin 29 uM 4.5277 3.4874e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR146C

Top 10 functional gene interactors with YDR146C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SWI5 by heterozygous co-sensitivity:

Query Interactor Correlation
SWI5 COQ9 0.37127
SWI5 YDR049W 0.34639
SWI5 ECM11 0.33901
SWI5 COQ10 0.33281
SWI5 YLR040C 0.32981
SWI5 YFL012W 0.32901
SWI5 MNI2 0.32697
SWI5 RPN9 0.32387
SWI5 YIG1 0.32296
SWI5 YOR199W 0.31871

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SWI5 by homozygous co-sensitivity:

Query Interactor Correlation
SWI5 MLC2 0.47873
SWI5 KIN4 0.47701
SWI5 BEM3 0.45326
SWI5 YOL107W 0.44186
SWI5 MLP1 0.43851
SWI5 YGR269W 0.41321
SWI5 YEL007W 0.40625
SWI5 PTC2 0.40008
SWI5 YPL066W 0.39959
SWI5 OPT2 0.39874

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YDR146C

Other databases:

Visit YDR146C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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