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YDR123C / INO2



Section 1: Phenotypes.
Gene-drug relationships for YDR123C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR123C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for INO2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 7.08966 2.4167e-08
lapachol 500 uM 5.45285 8.9638e-07
fk506 0.1 ug/ml 4.77067 1.9328e-05
latrunculin 6.25 uM 4.69546 0.00012155
fk506 0.1 ug/ml 4.64537 2.7767e-05
emodin 500 uM 4.25255 8.5703e-05
no drug minimal media 0 4.04775 0.0049236
itraconazole 8.8 uM 3.98447 0.00011698
no drug minimal media 0 3.86045 0.0059373
no drug minimal media 0 3.84465 0.0060333

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for INO2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 61.1407 0.0001337
synthetic complete for BY4743 0 59.9014 0.00013929
synthetic complete for BY4743 0 51.9482 7.8551e-06
synthetic complete for BY4743 0 44.4794 5.4218e-08
synthetic complete for BY4743 0 44.3447 5.5045e-08
synthetic complete for BY4743 0 44.2836 0.00025477
minimal media 0 40.9117 < 1e-12
synthetic complete for BY4743 0 39.3564 < 1e-12
tryptophan dropout 0 38.9481 < 1e-12
synthetic complete for BY4743 0 35.7707 3.4617e-12

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR123C

Top 10 functional gene interactors with YDR123C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with INO2 by heterozygous co-sensitivity:

Query Interactor Correlation
INO2 YIP1 0.37762
INO2 KIN1 0.36457
INO2 YDR426C 0.3449
INO2 BOP2 0.33645
INO2 HPR1 0.33122
INO2 HSP60 0.32991
INO2 TRS20 0.32707
INO2 YDR109C 0.32144
INO2 YLR199C 0.31916
INO2 RAD2 0.31525

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with INO2 by homozygous co-sensitivity:

Query Interactor Correlation
INO2 INO4 0.83599
INO2 ARG5,6 0.66673
INO2 LYS5 0.65776
INO2 ALT1 0.65298
INO2 YMR135W-A 0.63669
INO2 ACO2 0.6065
INO2 ORT1 0.59705
INO2 LYS1 0.56567
INO2 LPE10 0.56334
INO2 BOP2 0.5612

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YDR123C

Other databases:

Visit YDR123C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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