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YDR091C / RLI1



Section 1: Phenotypes.
Gene-drug relationships for YDR091C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR091C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RLI1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 4.54718 3.6855e-05
latrunculin 1.95 uM 3.88971 0.00023848
methotrexate 500 uM 3.02879 0.002413
methotrexate 500 uM 2.75371 0.0048164
fluconazole 31.25 uM 2.71041 0.0046757
chemdiv 41 500 uM 2.4909 0.0090603
telomerase inhibitor ix (Biomol) 500 uM 2.45789 0.0097878
wortmannin 50 uM 2.18293 0.018245
nocodazole 2 ug/ml 2.14924 0.018398
methotrexate 250 uM 2.03961 0.024859

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YDR091C

Top 10 functional gene interactors with YDR091C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RLI1 by heterozygous co-sensitivity:

Query Interactor Correlation
RLI1 MOT1 0.45507
RLI1 PXA2 0.4362
RLI1 SAN1 0.42879
RLI1 FMP16 0.42319
RLI1 SNG1 0.41878
RLI1 APT2 0.4146
RLI1 CDC60 0.41377
RLI1 RGR1 0.40941
RLI1 PFS1 0.40836
RLI1 MRP8 0.40426

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YDR091C

Other databases:

Visit YDR091C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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