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Yeast Fitness
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YDR075W / PPH3



Section 1: Phenotypes.
Gene-drug relationships for YDR075W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR075W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PPH3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
caspofungin 10 nM 8.06133 1.048e-10
caspofungin 10 nM 7.17702 2.2053e-09
itraconazole 17.7 uM 6.62312 1.5261e-08
itraconazole 4.4 uM 6.54079 2.0354e-08
itraconazole 8.8 uM 6.38099 3.5592e-08
fluconazole 130.6 uM 6.05489 1.1115e-07
fenpropimorph 4.7 uM 5.9844 1.421e-07
acriflavinium hydrochloride 250 uM 5.74235 3.2962e-07
itraconazole 4.4 uM 5.68537 4.0159e-07
itraconazole 17.7 uM 5.66192 4.3556e-07

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for PPH3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mms 0.002 % 15.8747 0.0019723
mitomycin c 1000 uM 15.6303 < 1e-12
streptozotocin 2000 uM 15.2629 < 1e-12
mitomycin c 1000 uM 15.0042 < 1e-12
mechlorethamine 62.5 uM 14.5115 0.00035475
mms 0.002 % 13.7028 < 1e-12
cisplatin 66 uM 13.3408 < 1e-12
synthetic complete for BY4743 0 13.2692 5.6445e-08
mechlorethamine 62.5 uM 13.0934 0.0028912
camptothecin 30000 ug/ml 12.1374 < 1e-12

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR075W

Top 10 functional gene interactors with YDR075W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with PPH3 by heterozygous co-sensitivity:

Query Interactor Correlation
PPH3 BTN2 0.48064
PPH3 XYL2 0.4421
PPH3 TMS1 0.4408
PPH3 BOP2 0.42697
PPH3 PTC2 0.41815
PPH3 UBC12 0.4163
PPH3 ATE1 0.41498
PPH3 PPZ2 0.41168
PPH3 RGA2 0.40612
PPH3 LSB1 0.40383

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with PPH3 by homozygous co-sensitivity:

Query Interactor Correlation
PPH3 PSY2 0.85521
PPH3 SAE2 0.63604
PPH3 SHU1 0.58819
PPH3 REV1 0.56368
PPH3 PTC2 0.56162
PPH3 RAD59 0.5553
PPH3 YOR345C 0.55272
PPH3 YJL185C 0.54365
PPH3 SHU2 0.54034
PPH3 SLX4 0.53769

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YDR075W

Other databases:

Visit YDR075W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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