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Yeast Fitness
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YDR073W / SNF11



Section 1: Phenotypes.
Gene-drug relationships for YDR073W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR073W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SNF11 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 250 uM 5.62829 0.015074
trichostatin A 3.91 uM 5.4619 2.5902e-06
fenpropimorph 4.7 uM 4.11108 7.839e-05
nocodazole 2 ug/ml 3.9789 0.00011904
itraconazole 8.8 uM 3.71109 0.00027277
5-fluorocytosine 15.6 uM 3.60304 0.00037841
itraconazole 8.8 uM 3.05127 0.0018702
5-fluorocytosine 15.6 uM 3.03434 0.0019599
fenpropimorph 2.3 uM 2.90378 0.0028004
itraconazole 4.4 uM 2.72598 0.0044899

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SNF11 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 200 uM 17.4872 < 1e-12
latrunculin 0.78 uM 12.2123 0.0033192
latrunculin 0.78 uM 9.63692 0.0052984
fk506 100 uM 7.93345 1.5279e-09
hgcl2 62.5 uM 7.82868 2.055e-09
wiskostatin 29 uM 7.81335 2.1464e-09
mncl2 2 mM 7.55709 4.4569e-09
fk506 200 uM 7.3217 8.7747e-09
latrunculin 0.78 uM 7.30057 0.0026533
synthetic complete for BY4743 0 7.05261 1.7439e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR073W

Top 10 functional gene interactors with YDR073W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SNF11 by heterozygous co-sensitivity:

Query Interactor Correlation
SNF11 YDR061W 0.57098
SNF11 FMP16 0.56441
SNF11 ENT2 0.55198
SNF11 YPL216W 0.51443
SNF11 ARO10 0.5025
SNF11 YMR114C 0.49612
SNF11 IRC2 0.4934
SNF11 UBC5 0.49134
SNF11 KEL1 0.48963
SNF11 ISY1 0.48401

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SNF11 by homozygous co-sensitivity:

Query Interactor Correlation
SNF11 SNC1 0.63477
SNF11 YJL055W 0.59623
SNF11 RCK1 0.59114
SNF11 IMH1 0.58031
SNF11 YML096W 0.57538
SNF11 KIN82 0.57379
SNF11 SYT1 0.56827
SNF11 NIF3 0.55244
SNF11 YPL105C 0.54809
SNF11 OSH3 0.54432

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YDR073W

Other databases:

Visit YDR073W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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