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Yeast Fitness
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YDR069C / DOA4



Section 1: Phenotypes.
Gene-drug relationships for YDR069C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR069C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for DOA4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 250 uM 4.96984 0.019092
fenpropimorph 4.7 uM 4.5206 2.083e-05
amphotericin b 0.62 uM 4.38349 3.262e-05
tryptanthrin 250 uM 4.20452 9.8249e-05
fenpropimorph 2.3 uM 4.09122 8.3497e-05
amphotericin b 0.62 uM 4.08713 8.4588e-05
doxorubicin 62.5 uM 4.07762 8.7178e-05
itraconazole 8.8 uM 3.70196 0.00028046
anisomycin 62.5 uM 3.69192 0.00028917
cantharidin 250 uM 3.58391 0.00055448

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for DOA4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 11.776 3.6074e-06
synthetic complete for BY4743 0 10.6592 7.0118e-06
synthetic complete for BY4743 0 8.54046 2.9953e-05
synthetic complete for BY4743 0 8.01617 4.4991e-05
rapamycin 9 nM 6.02955 0.01321
synthetic complete for BY4743 0 5.47223 0.015905
synthetic complete for BY4743 0 5.3471 0.016621
synthetic complete for BY4743 0 5.3356 0.016689
rapamycin 9 nM 5.30483 0.016873
mms 0.002 % 5.29906 0.016908

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR069C

Top 10 functional gene interactors with YDR069C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with DOA4 by heterozygous co-sensitivity:

Query Interactor Correlation
DOA4 MAP1 0.53627
DOA4 YDR114C 0.46962
DOA4 VPS41 0.46469
DOA4 YIP1 0.46108
DOA4 RIB5 0.45426
DOA4 RRP1 0.44703
DOA4 VPS34 0.43711
DOA4 PWP1 0.43681
DOA4 LCB5 0.43331
DOA4 LSM6 0.43207

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YDR069C

Other databases:

Visit YDR069C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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