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Yeast Fitness

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YDR062W / LCB2

Section 1: Phenotypes.
Gene-drug relationships for YDR062W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR062W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for LCB2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
myriocin 0.15 ug/ml 15.9088 < 1e-12
cantharidin 250 uM 7.74842 0.0081256
rhizoxin 200 uM 6.84667 4.7951e-08
ketoconazole 11.8 uM 6.64525 2.8142e-06
wiskostatin 29 uM 6.25221 2.6202e-07
5-fluorouracil 76.8 uM 4.62203 2.9703e-05
cantharidin 250 uM 3.93053 0.029527
tryptanthrin 250 uM 3.85156 0.00026524
cantharidin 250 uM 3.82025 0.031098
nocodazole 2 ug/ml 3.71767 0.00026734

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YDR062W

Top 10 functional gene interactors with YDR062W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with LCB2 by heterozygous co-sensitivity:

Query Interactor Correlation
LCB2 CLC1 0.49491
LCB2 VPS69 0.47811
LCB2 YDL068W 0.47569
LCB2 IKI3 0.46658
LCB2 SCD5 0.45678
LCB2 LTV1 0.45423
LCB2 THS1 0.45326
LCB2 CAF17 0.44538
LCB2 CBF2 0.44451
LCB2 MDM12 0.44429

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YDR062W

Other databases:

Visit YDR062W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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