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Yeast Fitness
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YDR059C / UBC5



Section 1: Phenotypes.
Gene-drug relationships for YDR059C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR059C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for UBC5 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
fenpropimorph 1.2 uM 5.19522 2.1673e-06
itraconazole 8.8 uM 4.14076 7.1322e-05
fluconazole 31.25 uM 3.84432 0.00018112
amphotericin b 0.62 uM 3.76547 0.00023096
itraconazole 4.4 uM 3.5424 0.00045384
fluconazole 31.25 uM 3.37377 0.00074668
itraconazole 4.4 uM 3.25868 0.0010417
aphidicolin glycinate 125 uM 3.13386 0.0018398
paraquat 5000 uM 3.12871 0.0018646
methotrexate 125 uM 3.08513 0.0020874

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for UBC5 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
rapamycin 9 nM 43.3605 0.00026573
rapamycin 9 nM 8.63701 0.0016322
wiskostatin 29 uM 6.85593 3.4069e-08
rapamycin 9 nM 6.80784 0.010451
synthetic complete for BY4743 0 5.25092 0.017204
mechlorethamine 62.5 uM 4.3222 0.024791
latrunculin 0.78 uM 3.95604 0.02918
cadmium chloride 7.81 uM 2.93642 0.0029596
synthetic complete for BY4743 0 2.72316 0.036178
mechlorethamine 62.5 uM 2.55472 0.062553

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR059C

Top 10 functional gene interactors with YDR059C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with UBC5 by heterozygous co-sensitivity:

Query Interactor Correlation
UBC5 YDR061W 0.63316
UBC5 IRC2 0.59157
UBC5 YPL216W 0.59152
UBC5 YMR114C 0.57263
UBC5 BOP2 0.56229
UBC5 SAN1 0.55984
UBC5 YNR018W 0.54541
UBC5 PPR1 0.53615
UBC5 PST1 0.53553
UBC5 YBR242W 0.53425

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with UBC5 by homozygous co-sensitivity:

Query Interactor Correlation
UBC5 SPH1 0.59357
UBC5 YNL295W 0.57191
UBC5 DCI1 0.56639
UBC5 STF2 0.54579
UBC5 ALK1 0.54483
UBC5 ERP3 0.50004
UBC5 YPR078C 0.49998
UBC5 YLR287C 0.4996
UBC5 CLB3 0.48785
UBC5 YDR063W 0.48257

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YDR059C

Other databases:

Visit YDR059C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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