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Yeast Fitness
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YDR023W / SES1



Section 1: Phenotypes.
Gene-drug relationships for YDR023W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR023W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SES1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
chemdiv 41 500 uM 6.23607 2.7449e-07
acriflavinium hydrochloride 250 uM 5.56703 6.0468e-07
drofenine hydrochloride 750 uM 4.79229 8.4584e-06
floxuridine 80000 uM 4.72696 1.052e-05
mechlorethamine 500 uM 4.1436 7.0677e-05
latrunculin 6.25 uM 3.97543 0.00054337
metergoline 250 uM 3.95459 0.00012847
trifluoperazine dihydrochloride 31.25 uM 3.87762 0.00024666
mechlorethamine 500 uM 3.79815 0.00020888
fluconazole 16.3 uM 3.58385 0.00040088

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YDR023W

Top 10 functional gene interactors with YDR023W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SES1 by heterozygous co-sensitivity:

Query Interactor Correlation
SES1 BBP1 0.47825
SES1 PPA2 0.41565
SES1 HSH49 0.40158
SES1 PHM8 0.40125
SES1 GAB1 0.37163
SES1 GPI1 0.36733
SES1 YJL202C 0.36439
SES1 LIP1 0.3618
SES1 ATP15 0.35908
SES1 YAE1 0.35895

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YDR023W

Other databases:

Visit YDR023W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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