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YDR015C / YDR015C



Section 1: Phenotypes.
Gene-drug relationships for YDR015C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDR015C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YDR015C Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 11.4443 < 1e-12
methotrexate 500 uM 11.4241 < 1e-12
lapachol 1000 uM 6.32395 4.3445e-08
trichlormethine 1000 uM 4.59825 1.6126e-05
mechlorethamine 500 uM 4.09389 8.2792e-05
k2cr2o7 6.25 uM 4.0844 0.00013806
bufexamac 1000 uM 3.63096 0.00034786
bufexamac 1000 uM 3.4814 0.00054413
mechlorethamine 500 uM 3.37104 0.00075266
tryptanthrin 250 uM 3.1601 0.0017184

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YDR015C Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nocodazole 10 ug/ml 8.16047 9.2241e-08
methotrexate 250 uM 4.98876 1.7308e-05
allyl disulfide 0.06 % 4.85589 1.3195e-05
nitric oxide 800 uM 4.71766 3.5409e-05
mms 0.002 % 4.49668 0.023033
mechlorethamine 62.5 uM 3.90653 0.029859
ph4 8 3.79968 0.00028635
synthetic complete for BY4743 0 3.78014 0.0018006
ph4 7.5 3.74952 0.00073375
angelicin 62.5 uM 3.32007 0.0019044

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDR015C

Top 10 functional gene interactors with YDR015C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YDR015C by heterozygous co-sensitivity:

Query Interactor Correlation
YDR015C MCH4 0.45183
YDR015C MNN5 0.39015
YDR015C YDR026C 0.37845
YDR015C MDH3 0.3668
YDR015C TNA1 0.36668
YDR015C BSC6 0.36492
YDR015C MNN1 0.36047
YDR015C ERV15 0.35954
YDR015C YJL185C 0.35923
YDR015C YPL206C 0.35582

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with YDR015C by homozygous co-sensitivity:

Query Interactor Correlation
YDR015C PCL1 0.55877
YDR015C PTP2 0.52678
YDR015C YKL061W 0.52472
YDR015C TWF1 0.52018
YDR015C YMR171C 0.50392
YDR015C YOR325W 0.49528
YDR015C ARF3 0.49504
YDR015C EMP46 0.49452
YDR015C YKL162C 0.49134
YDR015C OAC1 0.48829

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YDR015C

Other databases:

Visit YDR015C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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