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Yeast Fitness
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YDL215C / GDH2



Section 1: Phenotypes.
Gene-drug relationships for YDL215C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL215C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GDH2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 15.5317 < 1e-12
caspofungin 10 nM 12.1613 < 1e-12
caspofungin 10 nM 11.8325 < 1e-12
clozapine 500 uM 11.2396 < 1e-12
caspofungin 10 nM 9.43317 2.6416e-12
drofenine hydrochloride 750 uM 8.82687 9.2774e-12
caspofungin 10 nM 7.95728 1.4914e-10
wiskostatin 29 uM 7.71241 4.294e-09
clotrimazole 1 uM 7.42352 9.3603e-10
bufexamac 1000 uM 6.86029 6.6598e-09

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for GDH2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 3.40259 0.013606
ph4 7.5 3.39432 0.001616
methotrexate 250 uM 3.22115 0.0017093
nystatin 10 uM 3.19979 0.0047475
lovastatin 154.5 uM 2.90795 0.0036753
synthetic complete for BY4743 0 2.82246 0.0090421
mitomycin c 1000 uM 2.60991 0.0074136
mitomycin c 1000 uM 2.55904 0.0083315
floxuridine 3.37 uM 2.41178 0.011617
synthetic complete for BY4743 400 uM 2.39538 0.014195

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDL215C

Top 10 functional gene interactors with YDL215C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with GDH2 by heterozygous co-sensitivity:

Query Interactor Correlation
GDH2 WHI2 0.55101
GDH2 YLR296W 0.52592
GDH2 YLR290C 0.52117
GDH2 SWR1 0.51295
GDH2 ECI1 0.5127
GDH2 YLR280C 0.49603
GDH2 VPS35 0.49331
GDH2 PEP8 0.49132
GDH2 GUF1 0.48779
GDH2 YLR294C 0.48356

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with GDH2 by homozygous co-sensitivity:

Query Interactor Correlation
GDH2 YCP4 0.57649
GDH2 AGX1 0.54796
GDH2 YAT2 0.52525
GDH2 MEI4 0.51371
GDH2 DAK2 0.49778
GDH2 YER079W 0.49609
GDH2 VBA3 0.49514
GDH2 AVT1 0.4946
GDH2 YBR108W 0.4932
GDH2 TPO2 0.49262

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YDL215C

Other databases:

Visit YDL215C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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