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Yeast Fitness

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YDL209C / CWC2

Section 1: Phenotypes.
Gene-drug relationships for YDL209C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL209C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CWC2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorocytosine 15.6 uM 5.00038 4.2006e-06
paraquat 2000 uM 4.7645 1.9676e-05
itraconazole 37.6 uM 4.43876 2.7239e-05
nicardipine hydrochloride 500 uM 4.24818 5.0551e-05
5-fluorouracil 38.5 uM 3.96598 0.00012397
bufexamac 1000 uM 3.71773 0.00026729
methotrexate 250 uM 3.51773 0.0004885
bufexamac 1000 uM 3.5096 0.00050045
doxorubicin 62.5 uM 3.23473 0.0011156
aminopterin 125 uM 3.18878 0.0015944

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YDL209C

Top 10 functional gene interactors with YDL209C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with CWC2 by heterozygous co-sensitivity:

Query Interactor Correlation
CWC2 SHR3 0.40941
CWC2 SGT1 0.37466
CWC2 GAB1 0.37408
CWC2 GPI13 0.3709
CWC2 SFI1 0.37021
CWC2 HSP31 0.36751
CWC2 YPD1 0.36421
CWC2 YLL037W 0.36164
CWC2 SNU23 0.35919
CWC2 YGR265W 0.35714

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YDL209C

Other databases:

Visit YDL209C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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