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YDL182W / LYS20



Section 1: Phenotypes.
Gene-drug relationships for YDL182W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL182W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for LYS20 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 250 uM 7.22368 0.009315
cantharidin 250 uM 7.18421 0.0094148
cantharidin 250 uM 7.15957 0.0094778
cantharidin 250 uM 6.85688 0.010307
cantharidin 250 uM 6.84044 0.010355
cantharidin 250 uM 6.79351 0.010494
cantharidin 200 uM 6.52178 1.2088e-07
allyl sulfide 0.12 % 4.7183 2.2491e-05
itraconazole 17.7 uM 4.43174 2.7871e-05
dihydromotuporamine C 15 uM 4.20844 9.7158e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for LYS20 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
sorbitol 1.5 M 22.6196 3.2114e-10
synthetic complete for BY4743 0 18.291 0.00017827
cadmium chloride 7.81 uM 8.95664 9.0607e-11
synthetic complete for BY4743 0 5.41459 0.0014539
licl 150 mM 5.05975 7.1859e-06
myriocin 0.2 ug/ml 4.91636 5.5651e-05
licl 150 mM 4.89848 1.1624e-05
mncl2 2 mM 4.5712 3.0676e-05
minimal media 0 4.48266 0.00016384
rapamycin 9 nM 4.05788 0.013487

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDL182W

Top 10 functional gene interactors with YDL182W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with LYS20 by heterozygous co-sensitivity:

Query Interactor Correlation
LYS20 EAF5 0.38863
LYS20 TSC13 0.37899
LYS20 YPR099C 0.373
LYS20 LEA1 0.37051
LYS20 ATP2 0.36631
LYS20 RPL8A 0.34261
LYS20 OTU2 0.33875
LYS20 YRB2 0.33729
LYS20 NSE1 0.33694
LYS20 RPS23A 0.33389

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with LYS20 by homozygous co-sensitivity:

Query Interactor Correlation
LYS20 MRL1 0.64136
LYS20 YJL119C 0.59617
LYS20 MMP1 0.5934
LYS20 YLR456W 0.59171
LYS20 NHP6A 0.59038
LYS20 MNI2 0.58127
LYS20 ALY2 0.5804
LYS20 ACO2 0.56191
LYS20 GSM1 0.55892
LYS20 IMD3 0.55787

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YDL182W

Other databases:

Visit YDL182W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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