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YDL170W / UGA3



Section 1: Phenotypes.
Gene-drug relationships for YDL170W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL170W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for UGA3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 250 uM 7.08091 0.0096835
wiskostatin 29 uM 6.52971 1.1817e-07
latrunculin 3.91 uM 5.42521 2.8823e-06
nocodazole 2 ug/ml 5.20883 2.069e-06
ketoconazole 11.8 uM 4.99173 6.6535e-05
cantharidin 250 uM 4.39052 5.7794e-05
dna protein kinase inhibitor 0 4.38679 5.8414e-05
floxuridine 80000 uM 4.37647 3.3373e-05
drofenine hydrochloride 750 uM 4.27254 4.6734e-05
propyl disulfide 0.49 % 3.81497 0.00029363

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for UGA3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 8.90141 0.0014951
myriocin 0.2 ug/ml 7.57421 2.6464e-07
nocodazole 10 ug/ml 6.48446 2.1217e-06
fk506 0.1 ug/ml 6.0177 4.0844e-07
5-fluorouracil 38.5 uM 5.5691 3.7676e-06
synthetic complete for BY4743 0 5.09679 0.018203
mncl2 2 mM 5.09469 6.4735e-06
sorbitol 1 M 4.6393 2.5087e-05
fk506 0.05 ug/ml 4.58093 2.9809e-05
cadmium chloride 7.81 uM 4.36466 5.6282e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDL170W

Top 10 functional gene interactors with YDL170W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with UGA3 by heterozygous co-sensitivity:

Query Interactor Correlation
UGA3 ATG19 0.38281
UGA3 RPS22B 0.37685
UGA3 NDT80 0.37608
UGA3 YIP4 0.36935
UGA3 YLR413W 0.35891
UGA3 OPI10 0.35825
UGA3 AFG1 0.34988
UGA3 MKK2 0.34732
UGA3 YOL047C 0.34714
UGA3 BFA1 0.34666

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with UGA3 by homozygous co-sensitivity:

Query Interactor Correlation
UGA3 FSH2 0.57914
UGA3 ENT1 0.56299
UGA3 YJR015W 0.54498
UGA3 SHE3 0.5317
UGA3 ARN2 0.52455
UGA3 TGL3 0.51386
UGA3 NHP6B 0.51324
UGA3 YMR187C 0.50997
UGA3 OTU1 0.50681
UGA3 CMP2 0.50245

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YDL170W

Other databases:

Visit YDL170W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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